Levon

@HalabelianLab

Drug Discovery | Structural Biology | WDR protein family | PI at the SGC-University of Toronto | all opinions are my own.

SGC-Toronto thesgc.org/profile/toront… Joined March 2023

60 Following 23 Followers 7 Posts

Latest posts 3

Levon @HalabelianLab Jan 24, 2024

Our recent crystal structure of TREX1 in complex with a small molecule inhibitor is now available online.
#drugdiscovery #cachechallenge

rcsb.org/structure/8VL7

www.rcsb.org RCSB PDB - 8VL7: Co-crystal structure of human TREX1 in complex with an inhibitor Co-crystal structure of human TREX1 in complex with an inhibitor

Levon @HalabelianLab Mar 23, 2023

Exciting to share that our DCAF1 manuscript is now available online. It was great collaborating with the OICR team to advance this molecule into a nanomolar affinity DCAF1 ligand.

Structural Genomics Consortium (SGC) @thesgconline Mar 23, 2023

A cool approach utilizing the DEL technology and #MachineLearning models for the discovery and cellular target engagement of the first nanomolar DCAF1 ligand. This is a great example of collaborative science between @OICR_news, @Relay_Tx and the SGC.
pubs.acs.org/doi/10.1021/ac…
View quoted post on X

Levon @HalabelianLab Mar 22, 2023

Our recent structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor is now released. rcsb.org/3d-view/8GCY/1
#E3ligase