Hasanga Manikpurage

@HasangaDM

Genetic of cardiovascular diseases
Post-Doc Fellow @Cambridge_Uni @DPHPC 🇬🇧
PhD @universitelaval @IUCPQ 🇨🇦
MSc @univ_paris_cite @lvts🇫🇷

From 🇫🇷/🇱🇰

Paris, France inouyelab.org/home/people Joined March 2011

231 Following 94 Followers 123 Posts

Latest posts 5

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Hasanga Manikpurage @HasangaDM Oct 25, 2021

Wow!!! Many Thanks to @JeanetteErdmann, @konradtsawicki and @Circ_Gen for highlighting all the major points of our paper through this video!

Circulation: Genomic and Precision Medicine @Circ_Gen Oct 25, 2021

⚡️ Now online from Thériault + team: A Polygenic Risk Score for #CoronaryArteryDisease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men ahajournals.org/doi/10.1161/CI…

@AHAScience #AHAjournals #CardioGen

🎬 @JeanetteErdmann @konradtsawicki

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Hasanga Manikpurage @HasangaDM Jul 2, 2025

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @CommsMedicine. We benchmarked a set of PGS for CV traits available from the @PGSCatalog resource in different Canadian cohorts🇨🇦.
See more 👇🏽 - Link (OA):
nature.com/articles/s4385…
(1/5)

www.nature.com Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and... Communications Medicine - Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at...

Hasanga Manikpurage @HasangaDM Dec 6, 2024

Finally! Happy to share my 3rd PhD paper, now published in @ATHjournal! 🚀 This study explores the impact of integrating multiple independent lipid PRSs with a CAD-PRS for CAD incidence prediction in @uk_biobank.

👉🏽Link (Open Access! 📖): atherosclerosis-journal.com/article/S0021-…

Hasanga Manikpurage @HasangaDM Mar 18, 2024

Our latest meta-GWAS on aortic valve stenosis is available (>14K cases/>941K). 20(/32) new loci identified. RNAseq dataset from 500 patients highlights an enrichment in expression regulation at these loci & prioritizes candidate causal genes. See more nature.com/articles/s4146…

www.nature.com Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis... Nature Communications - Here the authors report 20 novel genomic risk loci for calcific aortic valve stenosis, the most common heart valve disorder. Using RNA sequencing in 500 human aortic valves,...

Hasanga Manikpurage @HasangaDM Nov 21, 2023

Love these small cartoons :)

Circulation: Genomic and Precision Medicine @Circ_Gen Nov 21, 2023

From @HasangaDM, @ArsenaultBenoit + team: Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis

ahajournals.org/doi/10.1161/CI…

@AHAScience #AHAjournals #CardioTwitter #Genetics

📽️@VibhuParcha

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