Great to see the fine piece of work in the public domain - a single amino acid in the Tie1 ectodomain (allowing cleavage vs. no cleavage) making the difference between angiogenesis and inflammation - nothing compares to the power of discoveries in definite genetic in vivo models!
This Research Letter identifies a long sought molecular switch in a pathway that regulates both blood vessel growth and inflammation: doi.org/10.1172/JCI204…
Mahak Singhal @Mahak906, Hellmut G. Augustin @HellmutAugustin & team @uniklinik_hd find that ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental #vascular programs.View quoted post on X
