Hsieh Lab

@HsiehLab

A lab @FredHutch obsessed with translation control and its impact on health and disease. #mRNAtranslation #prostatecancer #bladdercancer #physicianscientist

Seattle, WA research.fhcrc.org/hsieh/en.html Joined January 2019

608 Following 2.1K Followers 4.2K Posts

Latest posts 5

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Hsieh Lab @HsiehLab Oct 7

Ever wonder if tRNAs can regulate the identity of a cancer cell?

@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s4158…

www.nature.com tRNA dosage regulates lineage dependency and resistance in prostate cancer Nature - A tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.

Hsieh Lab @HsiehLab 8h

Go Human Biology Division @fredhutch!

Fred Hutch Cancer Center @fredhutch 2d

Three Fred Hutch researchers have earned @AmericanCancer grants to advance cancer research, from studying cancer-driving metabolic mutations to testing new treatments for rare liver cancer and investigating tumor-suppressing proteins. bit.ly/4BXWsET

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Hsieh Lab @HsiehLab 1d

AI slop

Hao Zhu Lab @Zhu_Lab 3d

People reviewing papers: Can u stop using AI? First, you can't upload papers onto AI, it's just not cool. 2nd, the reviews are crap-they make no sense, and they often produce stupid comments. 3rd, if you are going to use AI to review, can you take less than 4 months to do it?
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Hsieh Lab @HsiehLab Oct 9

Thanks @RuggeroDavide!

Davide Ruggero @RuggeroDavide Oct 8

Exciting new study from Andrew Hsieh @HsiehLab and team, revealing how a single tRNA can influence cancer cell identity, lineage plasticity, and therapeutic resistance. Another fascinating example of how the translation control specificity plays a much broader role in cancer!
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Hsieh Lab @HsiehLab Oct 3

Remarkable work from the Beronja Lab (Human Biology Division) @fredhutch (not on X) and Ying lab on demonstrating how p53 controls the strength and spatial organization of Wnt signaling which is critical for clonal outgrowths in tissue. Gradients matter. science.org/doi/10.1126/sc…

www.science.org Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal... Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis,...