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Toprim is different domain than HEPN. MNT can fit in here.
tRNA cleavage expriments from our MNT-HEPN study really helped for Eco2. The study:
pubmed.ncbi.nlm.nih.gov/33290744/
tRNA cleavage expriments from our MNT-HEPN study really helped for Eco2. The study:
pubmed.ncbi.nlm.nih.gov/33290744/
pubmed.ncbi.nlm.nih.gov HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation - PubMed Prokaryotic toxin-antitoxin (TA) systems are composed of a toxin capable of interfering with key cellular processes and its neutralizing antidote, the antitoxin. Here, we focus on the HEPN-MNT TA... nature.com/articles/s4159…View quoted post on X
Retron Eco2, another derivative of TA system HEPN-MntA (doi: 10.1093/nar/gkaa855), works as a trimeric complex that is activated by T2 phage endonuclease DenB, which cleaves msDNA & leads to RNA degradation.
Deoxydinucleotides can activate doughnut-shaped mutimeric HEPN ApeA nucleases for tRNA cleavage in the anticodon loop ✂️🛡🧬
Great work lead by Jonas, Giedrius and great team 💪🙌
Great work lead by Jonas, Giedrius and great team 💪🙌
🧬 We discovered how bacteria detect phage infections by sensing fragments of their own degraded DNA.View quoted post on X
Meet #ApeA – a #BacterialImmunity system activated by a novel signal - #Deoxydinucleotides.
Read our preprint: biorxiv.org/content/10.648…
A thread 🧵 (1/11)
Impressive work!
biorxiv.org/content/10.110…View quoted post on X
New type IX toxin/antitoxin system, anti-phage system Clover, where antitoxin produces 5′-triphosphothymidyl-3′5′-thymidine to inhibit the dGTPase toxin.
Impressive spacer selection mechanism by Cas9-adaptation supercomplexes - all pathway captured by #cryoEM #Cas9 🧬🧩🧵
'Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation'
Check out our preprint on #bioRxiv on the #Cas9-Cas1-Cas2-Csn2 supercomplex involved in #CRISPR spacer acquisition: biorxiv.org/cgi/content/sh…
Thread below.View quoted post on X
