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Jan Böttcher
@JBoettcherLab
Research group leader @TU_Muenchen. Interested in cancer immunology, T cells, DCs & immunity in space & time. find us on 🦋 @jboettcherlab.bsky.social
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Latest posts 5
Under certain conditions & using cross-dressing, intratumoral monocytes can do the job of cDC1s in supporting tumor-infiltrating CD8 T cells - Great work by @obenaufa @AnaisElewaut - to which we contributed some 🔬&🧫!
So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on @obenaufa.bsky.social rdcu.be/d1F7sView quoted post on X
Excited to share that our story on PGE2-mediated control of NK cell metastasis surveillance in lung tissue is now published in @CellReports
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author @AMPedde!
cell.com/cell-reports/f…
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author @AMPedde!
cell.com/cell-reports/f…
www.cell.com Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction... NK cells are critical for immunosurveillance of metastases. Pedde et al. reveal that tissue-seeding DTCs utilize the PGE2-EP2/EP4 signaling axis to induce NK cell dysfunction and immune escape... #DC2024 was a fantastic meeting packed with great talks and discussions - looking forward to #DC2026 in California, hosted by @Idoyaga_Lab @MaxKrummel @ZunigaLab
and with this... over & out #DC2024 & see you on #DC2026 that promises to be a fantastic meeting in amazing California and led by @Idoyaga_Lab @ZunigaLab & @MaxKrummel
That's all folks!View quoted post on X
