Journal of Cell Biology

Developmental elimination of electrical synapses by UNC-51/UNC-76–mediated vesicular transport. New study from Hao Huang, Yuzhi Yang, Lingfeng Meng and collegaues (Zhejiang University-University of Edinburgh Institute) hubs.la/Q04DBqqT0

#Development #CellSignaling

Bayazid, Bock et al. show that Rac1 deletion in mice causes postnatal cystic dysplasia resembling human multicystic dysplastic kidney disease. Rac1 organizes #actin to enable primary #cilia formation & tubular maturation in response to mechanical stress hubs.la/Q04DhqFl0

Explore recent #Tools papers published in JCB. These papers describe new methods for segmentation & quantitation of electron #microscopy data, expansion microscopy that reveals interactions between #organelles, & in vivo mapping of #peroxisome dynamics 👉 hubs.la/Q04B2m-J0

Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Phan, Reiter et al. show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation and maintenance. hubs.la/Q04C_yPp0

Dubenko et al. show that securin stabilized in response to #DNADamage signaling excessively accumulates during longer G2/M arrests. Upon commitment to #mitosis, completion of securin degradation is delayed, causing aberrant divisions and cell death hubs.la/Q04C_mjt0