Journal of Experimental Medicine

pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection. From @ElenaHerndezGa1, Miguel Galán, @salva_iborra and colleagues: hubs.la/Q04CVYbF0

📘 Part of #Interferons in Infection and Disease: hubs.la/Q04CVYY00

Xbp1 controls the reparative function of intestinal #ILC2s during #colitis. From Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Shiyang Li and colleagues: hubs.la/Q04CVY3j0

📘 Part of #Interferons in Infection and Disease: hubs.la/Q04CVYWr0

We're pleased to present a new collection on #Interferons in infection and disease. Explore JEM articles highlighting the latest advances in our understanding of the dynamic nature of interferons in immunity and disease. 👉 hubs.la/Q04CVPsj0

Yong Yu et al. show that culture-induced downregulation of the transcription factor Bcl11a derepresses the NADPH oxidase subunit Ncf1, driving oxidative stress & functional decline in HSCs; restoring Bcl11a w/ rapamycin preserves stem cell function hubs.la/Q04D6_kS0

Su, Lin, Simonelli, Marcotte, @panhammarstrom et al. investigate the cellular origins, B cell states, and functional properties of type I IFN–neutralizing #autoantibodies associated with severe #COVID19 and APS-1. hubs.la/Q04D6W4y0

#Autoimmunity #InfectiousDisease