Journal of General Physiology

Townsend, Thoreson et al. developed mice that selectively express the fluorescent glutamate reporter iGluSnFR3 in rod #photoreceptor cells. They find that rods maintain slow, stochastic release at 20-40 vesicles/s/ribbon under mesopic & photopic conditions hubs.la/Q04DzDY50

The epithelial Na⁺ channel is a protein that facilitates sodium movement from urine to blood and controls blood pressure. In this Perspective, Lawrence Palmer discusses unanswered questions regarding the function and regulation of this important channel. hubs.la/Q04Dhcmz0

Our November issue is here! hubs.la/Q04CTBGf0
🔬 Yamada, Karakas, and Denton (hubs.la/Q04CTBBn0) reveal how an extracellular pore motif controls inhibition of VRACs by DCPIB, providing new insights into the molecular basis of drug–channel interactions.

Dmytro Vasylyev, Sidharth Tyagi, Stephen G. Waxman et al. @YaleMed show that Nav1.7 and Nav1.8 #sodiumchannels work cooperatively to control sensory-neuron excitability. hubs.la/Q04CTpMg0

#Biophysics #MolecularPhysiology #ComputationalBiology #Nerve #IonChannels

Commentary: A new study by Hariharan et al. (hubs.la/Q04Cty6K0) reveals reduced function of brain capillary pericyte KATP channels in a mouse model of #Alzheimers disease. William F. Jackson discusses the questions raised by the study: hubs.la/Q04CtxLB0