Jay Shendure

@JShendure

Genomics technology developer. Developmental biology adult learner. Professor at @uwgenome @HHMINEWS @BrotmanBaty SeaHub @AllenInstitute /him.

Seattle, WA krishna.gs.washington.edu Joined May 2011

336 Following 15K Followers 586 Posts

Latest posts 5

Pinned post

Jay Shendure @JShendure Jul 31

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n

Jay Shendure @JShendure Oct 27

Our latest, sent on behalf of the outstanding but X-less Aidan Keith: OPTIMuS PRIME-Del uses paired prime editing to program targeted deletions at candidate enhancers, while concurrently replacing them w/ a molecular tag to verify & quantify deletions 1/7
biorxiv.org/content/10.648…

Jay Shendure @JShendure Oct 23

A phenomenal team-lead opportunity at the new @AllenInstitute AI BioDesign accelerator, please feel free to share to potential applicants!

jesse gray @yargessej Oct 23

We’re looking for a team-builder/proteome editor designer! If that sounds fun, check out: alleninstitute.org/careers/jobs?j….
View quoted post on X

Jay Shendure @JShendure Oct 8

Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)

1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/sc…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/…

Paper #1 covered in quoted thread. More on paper #2 here. 1/n

www.science.org A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse...

Jay Shendure @JShendure Jul 31

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n

View quoted post on X

Jay Shendure @JShendure Jul 30

New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee &
@CGBiar! Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n biorxiv.org/content/10.648…