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Jacobsen Lab

@JacobsenLab

Student-run Twitter account for the Jacobsen Group @HarvardCCB | Tweets by Eric signed ENJ
Cambridge, MA people.fas.harvard.edu/~jacobsengroup… Joined June 2020
115 Following 5.3K Followers 199 Posts

Latest posts 5

Jacobsen Lab @JacobsenLab
Tonight, we held our annual Paper of the Year meeting, during which we celebrated the great chemistry published in 2025. This year’s winner was the Stereoretentive Radical Cross-Coupling from @BaranLabReads nature.com/articles/s4158…
www.nature.com Stereoretentive radical cross-coupling Nature - Readily accessible enantioenriched sulfonylhydrazides and low loadings of an inexpensive achiral Ni catalyst can be used to control the stereochemical outcome of radical cross-coupling.
1 replies 13 reposts 134 likes 8.3K views View on X
Jacobsen Lab @JacobsenLab
Congratulations to @GabrielLovinger and Marcus Sak @msh_yi on their paper in @Nature! A HBD catalyst accelerates an SN2 pathway despite H-bonding to the nucleophile by preorganizing the ion pair into a reactive conformation, just like an enzyme would!

nature.com/articles/s4158…
www.nature.com Catalysis of an SN2 pathway by geometric preorganization Nature - A small-molecule (646 Da) hydrogen-bond-donor catalyst accelerates the SN2 step of an enantioselective Michaelis–Arbuzov reaction by recapitulating the geometric preorganization...
4 replies 26 reposts 189 likes 18K views View on X