Jamie Privratsky MD/PhD

JCI insight Verified account @JCI_insight · Oct 16

Presenting a novel axis that can fine-tune the immune response to glomerular and tubule cell damage:

Jamie R. Privratsky @JamiePrivratsky & team @DukeKidney @Duke_Anesthesia identify a novel myeloid cell-endothelial cell immunoregulatory axis, supporting a model whereby myeloid IL-1R1 activity constrains ER stress–mediated EBI3/IL27 secretion, thereby attenuating type I IFN expression in kidney endothelial cells and ameliorating
autoimmune nephritis.

The figure shows anti-IFNAR1 therapy abrogates kidney injury after NTS nephritis in mice lacking IL-1R1 specifically in myeloid cells (bottom); littermate controls (top).
#AKI #Nephrology #kidney #macrophage

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Nackley Lab @Nackley_Lab · Aug 21

Excited to announce that the Nackley Lab has been awarded a $3 million NIH R01 grant, building on research led by our own Dr. Nathaniel Hernandez (right)!

Learn about the team’s work on how fat cells communicate with the nervous system to influence pain:
anesthesiology.duke.edu/news/fat-cells…

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Vivianne Tawfik, MD, PhD @TawfikLab · May 15, 2025

Check out our new paper - cover story on @NatureNeuro - outlining a potential new target for pain treatment and which may explain the susceptibility of older adults to chronic pain

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Kurt zimmerman @Zimmermk1986 · May 10, 2025

Next year is the scary one! Thank you to everyone who planned the party and showed up (as well as those that couldn’t make it)! @sarah_jane210 @mesmith428 @OuhscN @Maryam7835Bibi

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