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Jeff Freiberg, MD, PhD

@JeffFreiberg

ID physician scientist studying S. aureus and antibiotic failure. Here mostly for the ID. Views my own.
Joined April 2020
334 Following 292 Followers 174 Posts

Latest posts 5

Jeff Freiberg, MD, PhD @JeffFreiberg
The study protocol for STOP-Vanc, our RCT looking at the use of MRSA nares PCR testing in an ICU, is finally published!

We are hoping to be done with enrollment soon and excited to see what we learn from this study! @VUMCLHS

trialsjournal.biomedcentral.com/articles/10.11…
link.springer.com Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin (STOP-Vanc): study protocol... Trials - Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP)...
0 replies 4 reposts 18 likes 1.9K views View on X
Jeff Freiberg, MD, PhD @JeffFreiberg
Honored to have our recent paper included as a @NatureComms Microbiology and Infectious Diseases Editor’s Highlight!

Thanks for featuring our work on antibiotic tolerance in S. aureus! @EricSkaar @VUMC_ID @VUMCPathology @VI4Research

nature.com/collections/je…
www.nature.com Microbiology and infectious diseases This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
2 replies 7 reposts 29 likes 3.1K views View on X
Jeff Freiberg, MD, PhD @JeffFreiberg
Incredibly proud to share the latest publication to result from my research furthering our understanding of why antibiotics fail, now out in @NatureComms!

The surprise contributor to antibiotic tolerance in S. aureus? Arginine metabolism! nature.com/articles/s4146…
www.nature.com Restriction of arginine induces antibiotic tolerance in Staphylococcus aureus Nature Communications - Utilising proteomic and transposon sequencing screens, Freiberg et al. identified arginine metabolism enzymes that impact tolerance to antibiotics in Staphylococcus aureus,...
Eric Skaar @EricSkaar Aug 8, 2024
Antibiotic tolerance in Staph aureus biofilms is induced by arginine depletion by ⁦@JeffFreiberg⁩ in ⁦@NatureComms⁩ opens up possible new ways to treat challenging Staph infections 🦠 💉 💊 nature.com/articles/s4146…
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3 replies 8 reposts 30 likes 17K views View on X
Jeff Freiberg, MD, PhD @JeffFreiberg
Broad spectrum antibiotics are the refuge of the poor diagnostician!
Brad Spellberg @BradSpellberg Jun 28, 2024
This is why only true experts should be allowed to make these decisions. So they aren't driven by irrational panic. And are instead driven by cold, hard facts. What bugs, cause what infxns, resistant to what abx? Start with that. Then you move to, ok, what abx cover those bugs.
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