Jian Shu

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@JianShuLab

Assistant Professor @MassGeneralNews @harvardmed, Associate Member @broadinstitute @ragoninstitute | Decoding and translating the languages of biology

Boston, MA jianshulab.org Joined August 2020

202 Following 764 Followers 36 Posts

Latest posts 5

Jian Shu @JianShuLab Sep 21

Chemical and transcriptomic barcodes of cellular senescence 🔬

RamanOmics integrates Raman imaging with spatial transcriptomics to map senescent cell states and their molecular signatures across aging and wound repair.

@NIH_CommonFund @sennetresearch

Nature Aging @NatureAging Sep 21

Online now!✨@kezhang2021 @xingjchen7 @f_monticolo @Salvato88775199 et al pair Raman imaging with spatial and single cell transcriptomics in aging and repair, and identify a lipid-linked Raman signature of p21+ cells @JianShuLab nature.com/articles/s4358…
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Jian Shu @JianShuLab Dec 15, 2025

VIP-OT: When perturbation meets vibrational imaging and optimal transport | After introducing optimal transport to single-cell genomics in 2019, we’re excited to bring OT to the field of vibrational imaging for the first time. 🥳 biorxiv.org/content/10.648…

www.biorxiv.org VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational... Dissecting the heterogeneous response of individual cells towards genetic and chemical perturbations is central to understanding the dynamic functions of cells and multicellular systems. However,...

Jian Shu @JianShuLab Dec 9, 2025

We are excited to share RamanOmics, the first multimodal framework integrating snRNA-seq, spatial transcriptomics, and label-free Raman imaging to map the spatial biochemical–molecular architecture of aging, senescence, and tissue repair. #NIH SenNet biorxiv.org/content/10.648…

www.biorxiv.org RamanOmics Decodes Spatial Vibrational-Molecular Architecture and Rewiring in Aging and Repair Aging and tissue repair involve multilayered and spatially heterogeneous remodeling across transcriptional, biochemical, and cellular dimensions, yet prevailing definitions rely on isolated molecular...

Jian Shu @JianShuLab Jul 18, 2025

Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings nature.com/articles/s4146…

www.nature.com Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph... Nature Communications - Cell segmentation remains a great challenge in high-resolution spatial-omics data. Here, the authors introduce a graph-based deep learning model that exploits transcript...

Jian Shu @JianShuLab Jul 16, 2025

When cellular reprogramming meets AI: towards de novo cell design | Nature Reviews Genetics nature.com/articles/s4157…

www.nature.com When cellular reprogramming meets AI: towards de novo cell design Nature Reviews Genetics - In this Journal Club, Jian Shu recalls a 2006 publication by Takahashi and Yamanaka as well as a 2021 paper introducing AlphaFold to discuss the fascinating potential of...