Look forward to seeing everyone in a few hrs, ASH workshop on functional precision medicine #ASH2025 @ASH_hematology @StJudeResearch @StJude
Jun Yang
@Junjyang
Pharmacologist and geneticist through and through
589 Following 924 Followers 569 Posts
Latest posts 5
New paper alert! Our team published in @NatureComms
on MeiHMM - a hidden Markov model that identifies meiotic nondisjunction error types in chromosomal abnormalities, like Down Syndrome, without parental data! #ComputationalBiology @StJudeResearch
doi.org/10.1038/s41467…
on MeiHMM - a hidden Markov model that identifies meiotic nondisjunction error types in chromosomal abnormalities, like Down Syndrome, without parental data! #ComputationalBiology @StJudeResearch
doi.org/10.1038/s41467…
www.nature.com Inferring chromosome segregation error stage and crossover in trisomic disorders with application... Nature Communications - The authors report a computational framework for determining the meiotic/mitotic origin of nondisjunction (NDJ) in trisomies without parental data. Applying this to Down... Kudos to @maud_maillard on her new paper in @jclinicalinvest! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into how cells strike the balance between de novo vs salvage purine synthesis.
Thiopurines for the treatment of cancer or autoimmune disease are limited by their toxicity.
@MaudMaillard @Junjyang @StJudeResearch identify germline NUDT5 variants that affect thiopurine metabolism and cytotoxicity in children with ALL, having implications for individualized thiopurine therapy.
jci.org/articles/view/…View quoted post on X
One of my favorite meetings!
We are a go! #ESHALL2025 started this morning! We are happy to welcome participants in Malahide for the 2,5-day ESH 4th Translational Research Conference on ALL
More information➡ bit.ly/4cy9jAS
Chairs: @kathrinbernt @CoolsJn @DombretHerve @ullawk
#ESHCONFERENCES #LEUsmView quoted post on X
