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Kalluri Lab

@KalluriLab

Research Lab of Dr. Raghu Kalluri. Unraveling the biology of cancer and other diseases to develop novel diagnostics and therapeutics.
Texas Medical Center, Houston raghukalluri.com/research Joined November 2013
49 Following 864 Followers 316 Posts

Latest posts 5

Kalluri Lab @KalluriLab
@KalluriLab is excited to highlight the innovative work of @JiangShaoyi and colleagues in our News & Views in @NatureNano! Their study harnesses virus-like EVs to enhance antigen presentation, T-cell activation, and cancer vaccine efficacy. 👍
Online now!

nature.com/articles/s4156…
www.nature.com Endogenous virus-like extracellular vesicles enhance the efficacy of cancer vaccines Nature Nanotechnology - Harnessing viral mimicry mechanisms enhances cancer vaccination by improving long-range antigen presentation and T cell activation.
Kalluri Lab @KalluriLab
Now online ➡️ we identify CDK8 as a resistance mechanism across several Kras inhibitors including daraxonrasib. Targeting CDK8 alone can overcome resistance and sensitize tumors to checkpoint immunotherapy with curative outcomes ‼️

link.springer.com/article/10.103…
link.springer.com CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and... The EMBO Journal - Mutations in KRAS are a dominant driver of pancreatic ductal adenocarcinoma (PDAC), with about 50% of patients presenting with KRASG12D mutations. Small molecule inhibitors...
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