Allon Klein Lab

@KleinLabHMS

Klein lab @HMS_SysBio. Fate decisions, dev bio, regeneration, single cell genomics, math, data sharing, rubber ducks. Tweets from lab members. Like/RT ≠ endorse

Joined September 2019

83 Following 2.2K Followers 69 Posts

Latest posts 5

Allon Klein Lab @KleinLabHMS Dec 28, 2025

Excited to see this out in Science!

We introduce CAGEs (Compartments with Amphiphilic Gel Envelopes): resilient, semi-permeable shells that overcome limits of droplet microfluidics.

CAGEs enable “multi-step genomics” at a massive scale.

Back-to-back with the Mazutis lab🔥

Ignas Maželis @IMazelis Dec 22, 2025

I am delighted to share that my main PhD project is finally out in Science Magazine!
I'm honored to have worked with so many talented colleagues and mentors that guided this journey and provided me an opportunity to contribute research!

science.org/doi/10.1126/sc…
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Allon Klein Lab @KleinLabHMS May 2, 2023

scRNA-seq is great for non-model organisms—with just a transcriptome you can discover new cell types. But for many marine organisms there's one big problem: SALT 🧂

A solution from our awesome student Tal Scully (1/7🧵)
biorxiv.org/content/10.110…

www.biorxiv.org A mannitol-based buffer improves single-cell RNA sequencing of high-salt marine cells Single-cell RNA sequencing (scRNA-seq) enables discovery of novel cell states by transcriptomic profiling with minimal prior knowledge, making it useful for studying non-model organisms. For most...

Allon Klein Lab @KleinLabHMS Mar 30, 2023

Shout out to @Nich, @jgungabeesoon, @Mate_Kiss on our paper doi.org/10.1016/j.cell… on heterogeneity in tumor neutrophils and why it matters. A great summary by @PittetLab below:

The Pittet Lab @PittetLab Mar 30, 2023

❔What is special about an immune system that successfully attacks tumors, compared to one that doesn’t?

Our new study in @CellCellPress led by @jgungabeesoon, @Nich and @Mate_Kiss_ aimed to address this question. A joint work with the great @KleinLabHMS

authors.elsevier.com/a/1gqieL7PXmbtw
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Allon Klein Lab @KleinLabHMS Feb 1, 2023

This is a fabulous collaboration between @KleinLabHMS and @ShouwenW, @Li_Li_666, and @FD_Camargo. The DARLIN mice is superior to CARLIN, and the single-cell multi-omic lineage tracing method is a great addition to single-cell genomics toolkits!

shouwen wang @ShouwenW Feb 1, 2023

Want to apply single-cell multi-omic lineage tracing to study your favorite system in mice at defined time point and with superior lineage resolution?
Jointly with @Li_Li_666 @SarahBowling15 @FD_Camargo, we present DARLIN, a superior lineage-tracing mouse biorxiv.org/content/10.110…

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Allon Klein Lab @KleinLabHMS Jan 1, 2023

It has been great to have @ShouwenW in our lab. Huge congratulations for starting his own lab at @Westlake_Uni ! Looking forward to more awesome work from your lab!

shouwen wang @ShouwenW Dec 30, 2022

Come join my group at Westlake university in the beautiful city of Hangzhou, China to study development and cell differentiation with advanced (multi-omic) lineage tracing approaches and machine learning!

shouwenwang-lab.com
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