Kohli Lab

@KohliLab

Studying DNA-modifying enzymes & pathways that add complexity to genomes. Tweets crowdsourced from overworked lab members & not Rahul Kohli unless tagged #RMK.

Philadelphia, PA kohlilab.org Joined October 2017

236 Following 620 Followers 114 Posts

Latest posts 5

Kohli Lab @KohliLab Mar 16

Detecting #cytosine mods like 5mC & 5hmC often comes at the cost of info about the underlying #DNA sequence. Our new Integrated #Sequencing strategy resolves that trade-off, reading both #genome *and* #epigenome.
@cenmag: tinyurl.com/3h9zbsr4
@J_A_C_S: tinyurl.com/jacsintseq

Kohli Lab @KohliLab Jan 29, 2025

Big congrats to Keisuke Yamada (@KohliLab/@ShiLab_UPenn grad student) for winning the 1st place poster award at last week's Deaminet 2025 6th International Conference on Base Editing, Prime Editing & Related Enzymes!

Kohli Lab @KohliLab Aug 1, 2024

Thanks to @PennMedBench for featuring our research on structural insights into the SOS response, a key pathway in the evolution of antibiotic resistance in bacteria. Check out the June 2024 Benchmarks issue & lead author @michael_cory22's tweetorial below!
mailchi.mp/uphs/penn-medi…

Kohli Lab @KohliLab May 17, 2024

Congrats to Michael! With thanks to great collaborators & the kind reviewer who echoed our excitement saying, “After ~50 years of study, we finally have a detailed model for how RecA catalyzes the autocleavage of LexA…” @BMBGGUPENN @PennChemistry @BB_UPenn

Kohli Lab @KohliLab Feb 8, 2024

Base editors are transformative precision genome editing tools. But do we really understand how Cas9 & DNA deaminases work together to shape editing outcomes? See how Kiara tackled this Q below to introduce both a powerful diversifying editor & new mechanistic model for BEs! 🧵👇

Kiara N. Berríos Adorno, Ph.D. @Berrios_KN Feb 7, 2024

The last lead author article from my PhD is out! In @NAR_open, we report our mechanistic study on how Cas9 and AID enzymes collaborate to shape base editing outcomes. Leveraging these insights, we create hyperactive BEs with the potential for targeted gene diversification. 1/

View quoted post on X