We’re excited to share our new perspective in @MolecularCell on designing programmable biological behavior! (1/3)
doi.org/10.1016/j.molc…
doi.org/10.1016/j.molc…
Latest posts 5
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) biorxiv.org/content/10.110…
www.biorxiv.org An improved model for prediction of de novo designed proteins with diverse geometries Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular,... We’re thrilled to share our new pre-print exploring how we can design and control dynamic proteins! (1/6) biorxiv.org/content/10.110…
In a new preprint, we describe an approach for multi-input gene regulation in mammalian cells, controlled by clinically approved drugs. Toward this goal, we engineer proteins of the nuclear hormone receptor family.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
www.biorxiv.org Multi-input drug-controlled switches of mammalian gene expression based on engineered nuclear... Protein-based switches that respond to different inputs to regulate cellular outputs, such as gene expression, are central to synthetic biology. For increased controllability, multi-input switches... Come work with us! We are hiring a specialist to do high-throughput testing of computationally designed proteins. Could be a BS/BA-level scientist looking to get experience before grad school, or someone looking to be long-term staff. Please share widely! aprecruit.ucsf.edu/JPF03924