Krische Lab

@KrischeLab

Synthetic Methods and Natural Product Synthesis @ UT Austin

Austin, TX sites.google.com/a/utexas.edu/t… Joined January 2019

131 Following 4.3K Followers 205 Posts

Latest posts 5

Krische Lab @KrischeLab Oct 24

Use of our iridium-catalyzed allylation on >700 mmol scale by Genentech & Paraza Pharma doi.org/10.1021/acs.jm…

pubs.acs.org Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based... Abstract. Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons fu

Krische Lab @KrischeLab Oct 24

For a recent application of our Ir-catalyzed crotylation on a challenging a-stereogenic alcohol, see Chao Li’s elegant syntheses of Nonthmicin and Ecteinamycin! doi.org/10.1021/jacs.6…

pubs.acs.org Scalable Total Syntheses of Nonthmicin and Ecteinamycin Reveal a Dual Antibacterial and Antitoxin... Abstract. Clostridioides difficile infection (CDI) is a severe diarrheal disease with substantial mortality, frequent recurrence, and limited treatment opt

Krische Lab @KrischeLab Aug 24

Here, we report the first examples of alcohol-mediated nitrile reductive C-C coupling. Congrats to Sebastian, Colin and Weijia! doi.org/10.1002/anie.9…

onlinelibrary.wiley.com Ruthenium‐Catalyzed Nitrile‐Acrylate Reductive Coupling by 2‐Propanol: Synthesis of Enantioenriched... The first nitrile reductive couplings beyond stoichiometric metals or metalloids are described. Using a ruthenium catalyst derived from RuHCl(CO)(PPh3)3 and Cy-BIPHEP, 2-propanol-mediated reductive...

Krische Lab @KrischeLab Jul 30

Many thanks to colleagues in Hokkaido for recognition of our work – and many thanks to students past and present for bringing it life! icredd.hokudai.ac.jp/akira-suzuki-a…

www.icredd.hokudai.ac.jp Akira Suzuki Awards Home We are excited to announce the recipients of the 2026 Akira Suzuki Awards. Congrat...

Krische Lab @KrischeLab Jul 27

Conjugation of phenyl and pyridyl bioisosteres via azole/azine C-H functionalization beyond premetalated reagents or photochemical promotions! doi.org/10.1021/acs.or…

pubs.acs.org Ruthenium-Catalyzed Conjugation of Phenyl and Pyridyl Bioisosteres to Azines/Azoles via Dearomative... Abstract. Using the inexpensive, air-stable ruthenium catalyst derived from RuHCl(CO)(PPh3)3 and the achiral ligands Cy-BIPHEP or dCypb, acetylenic bicyclo