Laboratory Investigation

@LIjournal

THE SCIENCE THAT ADVANCES #PATHOLOGY. Official Journal of @TheUSCAP. Editor-In-Chief: Dr. David M. Berman, M.D., Ph.D. (@virchow)

Palm Springs, CA linktr.ee/laboratoryinve… Joined January 2017

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Laboratory Investigation @LIjournal 20h

New from Laboratory Investigation 🔬 | The MONKEY Challenge benchmarks deep learning for inflammatory cell detection in kidney transplant biopsies, supporting quantitative, AI-assisted Banff lesion assessment.

🔗 van Midden et al. Read the article: buff.ly/upM84WJ

www.laboratoryinvestigation.org MONKEY Challenge: Machine-learning for Optimal detection of iNflammatory cells in KidnEY transplant... Accurate quantification of inflammatory cells in Periodic Acid-Schiff (PAS)-stained kidney transplant biopsies is essential for Banff classification but remains subjective and labor-intensive. To...

Laboratory Investigation @LIjournal Nov 1

Popular from Laboratory Investigation 🔬 | Standardizing pathology-based assessment of mature tertiary lymphoid structures as a potential biomarker for immunotherapy response.

🔗 Vanhersecke et al. Read the article: laboratoryinvestigation.org/article/S0023-…

Laboratory Investigation @LIjournal Oct 28

From the LI Archives 🔬 | Revisiting the September 2026 cover of Laboratory Investigation: tertiary lymphoid structure in thoracic NUT carcinoma highlighted by multiplex immunofluorescence. #LIArchives #CoverSpotlight

🔗 Wang et al. Read the article: buff.ly/G3J6r1c

Laboratory Investigation @LIjournal Oct 25

New from Laboratory Investigation 🔬 | Mutant p53 aggregation alters sialylated and sulfated glycan profiles and enhances Siglec-9 ligand availability in high-grade serous ovarian cancer.

🔗 Ikezaki et al. Read the article: buff.ly/iqsmRhY

www.laboratoryinvestigation.org Aggregation of Mutant p53 Alters Sialylated and Sulfated Glycan Profiles and Enhances Siglec-9... Mutant p53 proteins form aggregates, and the presence of such cytoplasmic p53 aggregates has predicted poor prognosis in several cancers including high-grade serous ovarian cancer (HGSOC). The...

Laboratory Investigation @LIjournal Oct 25

New from Laboratory Investigation 🔬 | Gastric cancers with a neuroendocrine carcinoma component show aggressive behavior, with ASCL1 and STAT3 linked to neuroendocrine differentiation and immune suppression.

🔗 Zhang et al. Read the article: buff.ly/HF0qqyl

www.laboratoryinvestigation.org Clinicopathologic and Molecular Characteristics of Gastric Cancer With a Neuroendocrine Carcinoma... Gastric cancers containing a neuroendocrine carcinoma (NEC) component show aggressive clinical behavior, but the clinicopathological significance of NEC components and the mechanisms associated with...