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Geert Bultynck 🇺🇦

@LMCSLeuven

The aim of Lab. Molecular & Cellular Signaling is to explore and exploit Ca2+ signaling in apoptosis and autophagy in health and disease. Views are my own.
K.U. Leuven, Belgium gbiomed.kuleuven.be/english/dep/50… Joined January 2011
442 Following 559 Followers 1.4K Posts

Latest posts 5

Geert Bultynck 🇺🇦 @LMCSLeuven
Our collaborative study on mechanisms of venetoclax resistance is now published in #Advanced #Science journal as an Early View from Advanced Portfolio. Please check LinkedIn for a more detailed explanation and gratitude to all contributors & collaborators. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…
advanced.onlinelibrary.wiley.com Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL-2 variants. G101V and D103Y reduce...
Geert Bultynck 🇺🇦 @LMCSLeuven
royalsocietypublishing.org/rsob/article/1…
Using IP3R KO cells expressing single IP3R isoforms, we show that anti-apoptotic BCL-2 proteins bind to and inhibit channel opening, Ca2+ signals & ER-mitochondrial Ca2+ transfers mediated by all three IP3R isoforms. So, BCL-2 is a general IP3R modulator!
royalsocietypublishing.org Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of... Abstract. Anti-apoptotic B-cell lymphoma 2 (BCL-2) controls inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca²+ signalling. As cells typically expre
Geert Bultynck 🇺🇦 @LMCSLeuven
Happy to share our @NatureComms on how ryanodine receptors control lysosomes to stay on call for autophagy or to get out of the cell for lysosomal secretion via the RyR2::ATP6v0a1 hub at ER-lysosomal contact sites! nature.com/articles/s4146…
www.nature.com Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal... Nature Communications - Endoplasmic reticulum (ER) and lysosomes mutually influence each other’s function. This study shows that ER-located ryanodine receptors physically connect with...
Geert Bultynck 🇺🇦 @LMCSLeuven
Another important moonlighting function of V-type ATPases by impacting other organelles!
JacksonLab @CBJacksonLab Dec 3, 2025
🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
nature.com/articles/s4146…
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