Polyak Lab

@LabPolyak

The official Kornelia Polyak Lab Twitter account. The Polyak Lab @DanaFarber Cancer Institute is dedicated to the molecular analysis of human breast cancer.

Boston, MA polyaklab.dana-farber.org Joined March 2022

118 Following 1.1K Followers 41 Posts

Latest posts 5

Polyak Lab @LabPolyak Jun 2, 2025

Our study on histone tail cleavage is out today in @NatureGenet . We found KDM4C prevents CTSL-mediated histone H3 tail clipping by modulating its recruiter GRHL2, reducing oxidative stress and promoting basal tumor growth. Congrats to @ZheqiL @nellage
nature.com/articles/s4158…

www.nature.com KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated... Nature Genetics - KDM4C regulates cathepsin L-mediated histone H3 N-terminal tail clipping through grainyhead-like 2 (GRHL2) methylation in breast cancer. This link between the cellular redox state...

Polyak Lab @LabPolyak Nov 23, 2024

We are thrilled to see our study about ZBTB7A in basal breast cancer is out in @CellReports . We identified ZBTB7A as an novel interactor and regulator of KDM5 using CRISPR screen, and characterized its functional impact on NFkB pathway. Congrats to all!

Cell Reports @CellReports Nov 21, 2024

ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer dlvr.it/TGJSQZ
View quoted post on X

Polyak Lab @LabPolyak Oct 24, 2024

🎃Polyak lab is getting ready for the MCO halloween pumpkin decoration contest! Huge shoutout to @MarieAnneGoyet1 and Andriana who made this piece of work based on the lab logo! Science and creativity go hand in hand!

Polyak Lab @LabPolyak Oct 3, 2024

We're excited to share that our study on aging has been published today in @Cancer_Cell. We used rat model to identify midkine as a promising driver in breast cancer tumorigenesis. Kudos to all the coauthors especially @yan_pengze !
cell.com/cancer-cell/fu…

www.cell.com Midkine as a driver of age-related changes and increase in mammary tumorigenesis Yan et al. reveal age-related changes in the rat mammary gland, identifying a unique aging-associated luminal progenitor population. Midkine treatment mimics the effects of aging and promotes mammary...

Polyak Lab @LabPolyak Jun 26, 2024

Thrilled to see our paper on KMT2C/2D in TNBC metastasis is out today in @NatureCellBio. We found loss of KMT2C/2D promotes brain metastasis via KDM6A actviation and MMP3 upregulation. Congrats to our twitterless Marco and all the coauthors!
nature.com/articles/s4155…