Spiegelman Lab

@LabSpiegelman

We study metabolic pathways regulating energy homeostasis, mitochondrial biogenesis, and muscle/adipose biology @DanaFarber @HarvardCellBio

Boston, MA spiegelmanlab.dana-farber.org Joined May 2021

163 Following 4.1K Followers 355 Posts

Latest posts 5

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Spiegelman Lab @LabSpiegelman Jul 21

Exercise helps improve depression and anxiety. With the Ben Greenwood lab, we wondered if irisin can help improve depression and anxiety in a rodent model. Yes, it looks promising. Feel free to check our preprint.
biorxiv.org/content/10.648…

www.biorxiv.org Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice Physical activity produces widespread benefits to physical and mental health, including protection against stress-related behavioral outcomes. However, the peripheral signals through which physical...

Spiegelman Lab @LabSpiegelman Oct 15

It is always fishing season somewhere in the world! Bruce and Shingo in the Florida Keys!

Spiegelman Lab @LabSpiegelman May 30

Another great annual retreat goes in the books. Our rule is you cant talk about what you work on, and it was so interesting. Props to the lab techs who each gave a great talk. Rockport is so lovely in the spring!

Spiegelman Lab @LabSpiegelman Apr 3

It is interesting to note, that much of the effects of irisin can be ascribed to the subsequent production of IL-33 by stromal cells within the adipose tissues. We never imagined such a mechanism in 2012! Big congrats to Mu and Gang for these determined efforts.

Spiegelman Lab @LabSpiegelman Apr 3

When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. nature.com/articles/s4225…

www.nature.com Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells Nature Metabolism - This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local...