ZhengLab

@LabZheng

Ning Zheng Laboratory at University of Washington

Joined August 2019

14 Following 304 Followers 14 Posts

Latest posts 5

Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again rdcu.be/EbdVwEStSHha

ZhengLab @LabZheng Feb 12

Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. rdcu.be/e3waV

ZhengLab @LabZheng Jun 4, 2024

Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein biorxiv.org/content/10.110…

www.biorxiv.org Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under... The transcription factor BACH1 regulates heme homeostasis and oxidative stress responses and promotes cancer metastasis upon aberrant accumulation. Its stability is controlled by two F-box protein...

ZhengLab @LabZheng May 15, 2024

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

www.biorxiv.org KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function[1][1]. As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently...

ZhengLab @LabZheng May 15, 2024

Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…

www.biorxiv.org Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of... UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal[1][1], a process that is tightly controlled by epigenetic regulation. By co-opting KBTBD4, a...