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The Matic Lab

@Lab_Matic

We are interested in ADP-ribosylation signaling in the DNA damage response and ageing. Account managed by lab members. @MPIAGE.
Cologne, Germany age.mpg.de/matic Joined May 2023
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The Matic Lab @Lab_Matic
Check out our latest #research on ADP-ribosylation signaling, published in@NatureComms and led by our former PhD student @ELongarini! 🥳  nature.com/articles/s4146…
www.nature.com Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by... Nature Communications - Ester-linked modifications are common but difficult to detect. Here, the authors present methods based on ester preservation and a sensitive antibody to reveal DNA...
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The Matic Lab @Lab_Matic
We are happy to share that our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out in Nature Chemical Biology! 🥂🎉☺️

nature.com/articles/s4158…
www.nature.com Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation Nature Chemical Biology - RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a...
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The Matic Lab @Lab_Matic
We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology.
biorxiv.org/content/10.110…
www.biorxiv.org Versatile Modular Antibodies for Sensitive and Specific Detection of Poly-ADP-Ribose ADP-ribosylation is a chemically versatile modification of proteins, RNA and DNA that regulates various important signaling pathways, many of which are implicated in human diseases. Despite being...