Fabien Le Grand

@LeGrandLab1

Researcher in muscle cell biology. Addicted to signaling pathways (Wnt, Tgfb, Bmp). PI at Institut NeuroMyoGène.

Lyon, France inmg.fr/le-grand/ Joined April 2018

460 Following 967 Followers 593 Posts

Latest posts 5

Fabien Le Grand @LeGrandLab1 Jul 24, 2024

With @GilbertLab , we designed a pipeline to study communications toward muscle stem cells during tissue regeneration. How do MuSCs re-quiesce? Check the work by our star students @GarciaPaulineJ & @Erik_Jacques_ in our new preprint.
biorxiv.org/content/10.110…

www.biorxiv.org Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an... Skeletal muscle regeneration is mediated by resident muscle stem cells that produce progeny to repair or recreate muscle. Critical to this function is the ability to transition between states of...

Fabien Le Grand @LeGrandLab1 Jun 6, 2024

I am delighted to share our newest paper. @GarciaPaulineJ found that Setdb1 is absolutely required for muscle tissue regeneration. This by keeping ancient viral elements silenced in muscle stem cells. @EJPRareDiseases @iNeuroMyoGene @AfmPresse

Developmental Cell @Dev_Cell Jun 6, 2024

Online now: Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation dlvr.it/T7wXZb
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Fabien Le Grand @LeGrandLab1 Oct 20, 2023

@AgenceRecherche j'ai recu, mercredi, mail de confirmation de votre part de l'enregistrement de notre pre-proposition PRC. Hier je reçoit un mail prétendant une "absence de confirmation", que notre projet ne sera pas considéré. Veuillez expliquer ces contradictions, je vous prie.

Fabien Le Grand @LeGrandLab1 Jun 9, 2023

Delighted to share our latest work on BioRxiv. During her PhD, @GarciaPaulineJ relentlessly studied the impact of removing the H3K9 methyltransferase Setdb1 in muscle stem cells. Strikingly she found Setdb1 is absolutely required for regeneration 1/n
biorxiv.org/content/10.110…

www.biorxiv.org Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and... Modulations in chromatin structure orchestrate gene expression and direct stem cell fate. More specifically, the Histone 3 Lysine 9 Methyltransferase SETDB1 controls transcriptional repression to...

Fabien Le Grand @LeGrandLab1 Dec 19, 2022

Check out Nicolas Rose study, out in Biomaterials. He navigated between three labs/co-supervisors during his PhD, and yet successfully created very tiny 3D myotubes between pillars. This is a new tool to measure the force generated by a single human muscle cell in health/disease.