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Liang Cheng, MD

@LiangChengMD

Professor of Pathology& Surgery(Urology) @BrownUniversity;Vice Chair,Director of Anatomic & Molecular Pathology @BrownPathology;Associate Director @BrownUCancer
Providence, RI vivo.brown.edu/display/lcheng… Joined June 2020
848 Following 3.7K Followers 1.1K Posts

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Liang Cheng, MD @LiangChengMD
On this World Book Day, I’m thrilled to announce the release of the Second Edition of Bladder Pathology, following the publication of the first edition in 2012. This fully updated, 880-page reference captures the most recent advances in diagnostic urologic pathology and is now available for purchase: amazon.com/dp/B0DRZ6FB7N

This essential volume bridges cutting-edge science with practical, evidence-based guidance for diagnosing and managing bladder diseases across diverse clinical settings. Incorporating the 2022 WHO Classification of Tumours and the most recent AJCC TNM staging, this edition expands on key developments in cancer genomics, molecular pathology, and diagnostic biomarkers. It also offers a deeper focus on therapeutic implications and clinicopathologic correlations, making it an indispensable resource in the era of precision medicine.

With over 1,000 high-quality color illustrations, Bladder Pathology provides comprehensive coverage of benign and malignant conditions, congenital anomalies, inflammatory and metaplastic disorders, and the evolving histologic subtypes of bladder cancer.  Designed for practicing pathologists, urologists, oncologists, and trainees, this book delivers a rigorous, up-to-date foundation for accurate diagnosis and personalized patient care.

In the age of precision genomics, this second edition highlights the expanding role of molecular pathology in diagnosis, tumor classification, and individualized treatment planning. It reflects the ongoing paradigm shift in urologic pathology - where evidence-based approaches and genomic insights are reshaping clinical practice.

With its comprehensive coverage, clarity, clinical relevance, and richly illustrated format, Bladder Pathology is an indispensable resource for navigating the complexity and diversity of bladder disease in contemporary medicine.

READ YOUR WAY!
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Liang Cheng, MD @LiangChengMD
Published in the October 2026 issue of European Urology @EUPlatinum (Impact Factor: 29), this collaborative work was led by Roger Li @UrogerliMD, Can Aydogdu @CanDAydogdu, Laura Bukavina @LauraBukavinaMD A must-read for anyone interested in bladder cancer! Great honor to be part of this work.
 @UroDocAsh @AndreaNecchi @apolo_andrea @SpiessPhilippe
This comprehensive review provides an integrated overview of the pathology, molecular characteristics, and clinical management of major bladder cancer subtypes, including squamous, adenocarcinoma/glandular, micropapillary, sarcomatoid, plasmacytoid, nested, and small cell neuroendocrine carcinoma. These tumors are biologically heterogeneous, often clinically aggressive, and frequently understaged on transurethral resection, supporting consideration of early radical cystectomy in selected high-risk patients.
 
Importantly, treatment response varies substantially by histology. Small cell neuroendocrine carcinoma demonstrates the clearest benefit from platinum/etoposide-based chemotherapy, while other subtypes show variable responses to conventional systemic therapies. Molecular profiling reveals potentially actionable alterations, including ERBB2 in micropapillary carcinoma, CDH1 loss in plasmacytoid carcinoma, FGFR3 alterations in nested carcinoma, and TP53/RB1 alterations in small cell carcinoma. Emerging evidence also supports potential roles for immune checkpoint inhibitors and antibody-drug conjugates.
 
We emphasizes that variant bladder cancers should not be managed using a uniform approach. Accurate histologic classification, quantification of subtype components, and molecular profiling are increasingly important for personalized treatment and future subtype-specific clinical trials.
 
Full article available at authors.elsevier.com/c/1nL8w14kpm4a…
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Liang Cheng, MD @LiangChengMD
Great honor to be part of this work.. a must read
Advanced Prostate Cancer Consensus Conference Verified account @APCCC_Lugano 6d
🧬 Are we underestimating rare prostate cancer histologies simply because we rarely look for them?

nature.com/articles/s4158…

Rare prostate cancer histologies: detection, characteristics and treatment

Rare #ProstateCancer histologies comprise less than 5% of cases but represent a clinically important and under-recognized group.
➡️These subtypes often show aggressive behaviour, atypical metastatic patterns and poorer outcomes, while remaining underrepresented in guidelines and trials.
➡️Accurate diagnosis increasingly depends on multiparametric MRI, immunohistochemistry and genomic profiling.
➡️Molecular alterations such as DNA🧬 repair defects, TP53/RB1 loss and mismatch repair deficiency may offer therapeutic opportunities, highlighting the need for subtype-specific evidence and prospective studies.

@bavilima , @UrogerliMD, @katcollmd, @neerajaiims, @PGrivasMDPhD, @Albert0Briganti, @AndreaNecchi, @LiangChengMD, @SpiessPhilippe

@Oncoalert 🚨 #LPCCC27
@Silke_Gillessen
@AOmlin
@ProfKHerrmann
@weoncologists
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Liang Cheng, MD @LiangChengMD
The December 2026 issue of Histopathology@Histo_Journal is out! Honored to have had the opportunity to collaborate and contribute three articles to this issue. Congratulations to all the authors on their excellent work!
🔹 Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape
pubmed.ncbi.nlm.nih.gov/42363647/
doi.org/10.1111/his.70…

🔹 Histological assessment of treatment effect in lymph node-positive breast cancer after neoadjuvant chemotherapy
pubmed.ncbi.nlm.nih.gov/42549549/
doi.org/10.1111/his.70…

🔹 Spermatocytic tumours containing an intratubular component: a multi-institutional study emphasizing diagnostic pitfall with germ cell neoplasia in situ
pubmed.ncbi.nlm.nih.gov/42549549/
doi.org/10.1111/his.70…
Liang Cheng, MD @LiangChengMD
Join or Renew Your ISUP Membership: isupweb.net/membership-joi…
📰 ISUP November 2026 Newsletter is out!

🔬 Stockholm Consensus Meeting highlights
🌍 Global outreach & new committees
📚 Education, mentorship & proficiency testing
🤝 Updates from CAP26 & IAP 2026

Read more: isupweb.net/isup-newslette…
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