Gabriel Loeb

Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.

Thank you to @kidneyomicsamps and @MagdalenaRiedlK for the thoughtful editorial on our paper functionalizing 𝘗𝘒𝘋1 variants and implications for polycystic kidney disease (ADPKD) genetic testing and treatment. DOI: 10.1681/ASN.0000001174 journals.lww.com/jasn/fulltext/…

Thank you @ASNKidney! Our lab is very grateful to receive the 2025 Carl W. Gottschalk Research Scholar Grant. Read more about the work here: kidneycure.org/pages/qa.aspx?….

Steven Pinker:
And if you’re still skeptical that universities are worth supporting, consider these questions: Do you think that the number of children who die every year from cancer is just about right?

Exciting paper by @CanaudLab in @jclinicalinvest--doi.org/10.1172/JCI176…. 1) Somatic mutation as a (presumably) very rare cause of FSGS, 2) Targeting the mutated gene PIK3CA is helpful in multiple mouse FSGS models, 3) Activity of podocyte targeted therapy in mouse FSGS.