Movement Disorders Journal

As genetic discoveries accelerate, an important question emerges: who will translate increasingly complex genetic results into meaningful clinical decisions?

In this insightful Viewpoint, Di Fonzo and Magrinelli explore the growing gap between genetic testing capabilities and the clinical expertise needed to interpret them.

The message is clear: sequencing is advancing rapidly. Our expertise must catch up! loom.ly/zC85OFw

In this Scientific Perspective, Scheperjans and colleagues provide an insightful overview of how the gut has evolved from a largely overlooked contributor to non-motor symptoms into a central focus of biological models of Parkinson’s disease. A must-read for anyone interested in the gut–brain axis and the future of PD research! loom.ly/btphAuw

Could targeting TGF-β signaling offer a potential therapeutic strategy for progressive supranuclear palsy (PSP)?

In this interesting study, Talarico and colleagues demonstrate that TGF-β inhibition attenuated tau hyperphosphorylation, dopaminergic neuronal loss, and astrocytic reactivity in PSP patient-derived organoids, offering a promising avenue for further investigation of disease-modifying therapies. loom.ly/5lHcyVk

In this article, the authors highlight a potential association between vitamin B6 deficiency and seizures in people with Parkinson’s disease. Among 144 patients studied, 3 had suspected epileptic events with B6 deficiency; 2 died following refractory status epilepticus.

CLINICAL REMINDER: Maintain a high index of suspicion for B6 deficiency when patients with PD develop new seizures or paroxysmal events. Early recognition and timely treatment may be critical.

[The FDA is now requiring updated warnings for carbidopa/levodopa products regarding vitamin B6 deficiency and associated seizures.] loom.ly/L2oYhhE

Evidence-based review analyses and clinical practice guidelines are complementary, not competing, tools. The @movedisorder EBM and EAN/MDS-ES Guideline committees explain how using such tools together leads to more informed patient-centered decisions. …mentdisorders.onlinelibrary.wiley.com/doi/full/10.10…