MDPI Biology

GRK2 biases CCR7 signaling in T cells: after CCL19 it promotes kinase-dependent arrestin-3 recruitment and rapid internalization; after CCL21 it slows internalization, favors Gαi2 and is required for chemotaxis. This provides a model of ligand-biased signaling at one GPCR.

Shamonda virus was found in the CNS of two horses in southern Germany with neurological signs. Both had severe lymphohistiocytic meningoencephalitis, with no genome in blood or non-CNS organs. Postmortem brainstem tissue is diagnostic; antemortem testing remains limited.

Platelets hold most circulating TDP-43: in one protocol, at least 95% of the protein in platelet-containing plasma was inside platelets. Hemolysis, clotting and cold-chain failures can confound the signal, so a blood biomarker needs standardized pre-analytical reporting first.

EGFR, HER2, ER and AR remain among the most actionable cancer targets, yet resistance rarely stays on one node. This review maps how mutations, overexpression, ligand loops and pathway crosstalk rewire signaling—and why combination and degrader strategies follow from that biology

🔔 The 7th Life Webinar focusing on NAMs is coming soon!
⏰ 16 Nov 2026, 15:00 CET Hosted by Prof. Dr. Maria Pilar Vinardell

Register to join this discussion: us02web.zoom.us/webinar/regist…

#NAMs #Toxicology #Webinar #MDPI