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Mohammad Fallahi-Sichani

@MFallahiSichani

Associate Professor @UVABME, PI for Laboratory of Systems Biology and Cancer Pharmacology, @UVACancerCenter, @MedicineUVA, @UVAEngineers. All views my own!
Charlottesville, VA fallahi-sichani-lab.com Joined May 2018
649 Following 513 Followers 275 Posts

Latest posts 5

Mohammad Fallahi-Sichani @MFallahiSichani
Happy to share our lab's paper published in @CellReports: led by talented PhD student, Yonatan Degefu at @UVABME, showing how cell state #plasticity (in #melanoma) is shaped by co-regulated, competitive, configurable interactions within the AP-1 network: cell.com/cell-reports/f…
www.cell.com Mechanistic modeling reveals a configurable AP-1 network governing cell-state heterogeneity and... Degefu et al. combine highly-multiplexed single-cell measurements with mechanistic modeling and machine learning to show how dimerization-dependent, co-regulated, and competitive AP-1 network...
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Mohammad Fallahi-Sichani @MFallahiSichani
Happy to share our lab's latest publication @PLOSCompBiol, led by our recent PhD graduate and #cancer researchers , Luisa Quesada @UVABME @UVACancerCenter, identifying Set1C/COMPASS as a novel #melanoma-enriched #epigenetic vulnerability. journals.plos.org/ploscompbiol/a…
journals.plos.org Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a... Author summary Cancer cells often rely on abnormal regulation of gene activity to support uncontrolled growth and survival. This regulation is controlled not only by genetic mutations, but also by...
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Mohammad Fallahi-Sichani @MFallahiSichani
Happy to share preprint of our lab's latest work led by talented PhD student, Luisa Quesada at @UVABME and @UVACancerCenter , applying a systematic multivariate analysis of chromatin complex dependencies to reveal Set1C/COMPASS as a #melanoma-enriched epigenetic vulnerability.
bioRxiv Cancer Bio @biorxiv_cancer Feb 14
Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability biorxiv.org/content/10.648… #biorxiv_cancer
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Mohammad Fallahi-Sichani @MFallahiSichani
It was a pleasure and great fun attending the CMBE meeting, presenting updates from our lab work on Cell State Plasticity and AP-1 network , led by @UVABME PhD student, Yonatan Degefu.
If you want to learn more about it, here is the link to the preprint:
pubmed.ncbi.nlm.nih.gov/41279149/
pubmed.ncbi.nlm.nih.gov Cell state plasticity emerging from co-regulated, competitive, and configurable interactions within... Cell state plasticity drives metastasis and therapy resistance in cancers. In melanoma, these behaviors map onto a melanocytic-to-mesenchymal-like continuum regulated by AP-1 transcription factors....
@BMES_CMBE @BMES_CMBE Jan 5
🧬🧩 One network. Many cell states. Constant rewiring.

Mohammed Fallahi-Sichani @MFallahiSichani (UVA) shows how the AP-1 co-regulatory network organizes discrete, heterogeneous, and reconfigurable cell states.

Biology, built to adapt.
#CMBE2026 #SystemsBiology
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Mohammad Fallahi-Sichani @MFallahiSichani
Excited to share our lab's latest work led by talented Yonatan Degefu, showing how cell state plasticity (in melanoma) is shaped by co-regulated, competitive, configurable interactions within the AP-1 transcription factor network.
@UVABME @UVACancerCenter
bioRxiv SysBio @biorxiv_sysbio Nov 8, 2025
Cell state plasticity emerging from co-regulated, competitive, and configurable interactions within the AP-1 network biorxiv.org/content/10.110… #biorxiv_sysbio
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