MGH JWChen Lab

Myeloperoxidase, a highly oxidizing enzyme, exerts anti-tumor activity in glioma after radiotherapy. This could help optimize host immune response and therapy for this devastating disease. sciencedirect.com/science/articl… @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH

D-mannose, a commonly available dietary supplement and a simple sugar, can improve neuroinflammation by suppressing oxidative stress and blocking phagocytosis. doi.org/10.1073/pnas.2… @PNASNews @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH @CaravanLabMGH

Great symposium on translational imaging of inflammation coming up at the end of October. Hope to see you there! i3.mgh.harvard.edu/inflammation/ @i3Symposium2021 @MGHCSB @MGHImaging @MGHMartinos @MGH_RI @MGHNeuroRad @JimBrinkMD @MatthiasNahrend @SwirskiLab @mghradchiefs @UCSFimaging

Does gadolinium deposition in the brain have clinical consequence? Lessons from animal studies. doi.org/10.1148/radiol… @radiology_rsna @MGHImaging @MGHCSB @i3MGH @MGH_RI @MGHNeuroRad

A more powerful molecular MRI agent (4-10X higher than conventional MRI agents) to report on myeloperoxidase activity, which reflects oxidative stress and damaging inflammation. doi.org/10.1021/acs.jm…. @MGHImaging @MGHCSB @MGHNeuroRad @harvardmed @MGH_RI @JMedChem