MND Research Australia

@MND_RIA

Motor Neurone Disease Research Australia has built & sustained MND research nationally for 40 yrs. MNDRA is the research arm of MND Australia.

Australia mndresearch.org.au Joined March 2015

400 Following 1.6K Followers 4.3K Posts

Latest posts 5

MND Research Australia @MND_RIA Feb 26, 2025

pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients | PNAS pnas.org/doi/10.1073/pn…

Interesting to see microglia changes are seen first then followed by oligodendrocytes and astrocytes - suggests cascade

MND Research Australia @MND_RIA Feb 25, 2025

Rethinking phase 2 trials in amyotrophic lateral sclerosis academic.oup.com/brain/article/…
Well-thought out discussion - basically if you want to run 6-month Phase 2 trials - use biomarkers for your go/no-go decision. If you want to use ALSFRS-R - you need a longer trial

academic.oup.com Rethinking phase 2 trials in amyotrophic lateral sclerosis There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

MND Research Australia @MND_RIA Feb 21, 2025

Characteristic symptoms of MND/ALS are preceded by sleep disturbances
Findings suggest that sleep disorders appear before the onset of motor impairment and respiratory issues
healthcare-in-europe.com/en/news/aml-sl…
science.org/doi/10.1126/sc…

healthcare-in-europe.com AML: sleep problems identified as early warning sign Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, or Lou Gehrig’s disease, is a severe neurodegenerative disease that leads to progressive paralysis of muscles involved in...

MND Research Australia @MND_RIA Feb 21, 2025

A lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection
Better alternative to intrathecal (spinal) injections
Potential for MND gene therapies?
Only tested in mice so far...
nature.com/articles/s4156…
news-medical.net/news/20250217/…

www.nature.com Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system Nature Materials - A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes...

MND Research Australia @MND_RIA Feb 21, 2025

Neurological Alliance Australia (NAA) (MND Australia area member) are advocating for the creation of a Taskforce for Neurological Conditions to urgently address six critical areas of need.
It takes just a few minutes to send an email to your local MP
countusin.good.do/naa/count-us-i…

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