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Priya Alexander, MD
@MPAlexanderMD
Renal Pathologist, Mayo Clinic, Rochester, MN. I love kidneys. Tweets are my own, not medical advice.
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To confirm the interstitial amyloid was ALECT2 amyloid.
The patient was Hispanic. ALECT2 was likely an incidental finding.
Check out this very timely publication ⬇️
Co-occurrence of systemic anti-neutrophil cytoplasmic antibody-associa… sciencedirect.com/science/articl…
The patient was Hispanic. ALECT2 was likely an incidental finding.
Check out this very timely publication ⬇️
Co-occurrence of systemic anti-neutrophil cytoplasmic antibody-associa… sciencedirect.com/science/articl…
Every biopsy teaches me something.
1. Don’t be restricted by the clinical presentation. Expect the unexpected.
2. A limited biopsy can still be worth a million 💰
Bx shows: FSGS ( no ANCA crescents)
Now see arrows.
Now see Congo red.
Interstitial amyloid (not AL).View quoted post on X
I have often paused thinking a case has fine dusting only to note that there is a generalized tissue ANA effect ( as seen here).
Just wanted to raise awareness to what is a probably well recognized diagnostic pitfall.
Just wanted to raise awareness to what is a probably well recognized diagnostic pitfall.
Immunofluorescence image of a glomerulus seen on this IgG stained section.
Patient has lupus with proteinuria.
Thoughts?View quoted post on X
Immunofluorescence image of a glomerulus seen on this IgG stained section.
Patient has lupus with proteinuria.
Thoughts?
Patient has lupus with proteinuria.
Thoughts?
Every biopsy teaches me something.
1. Don’t be restricted by the clinical presentation. Expect the unexpected.
2. A limited biopsy can still be worth a million 💰
Bx shows: FSGS ( no ANCA crescents)
Now see arrows.
Now see Congo red.
Interstitial amyloid (not AL).
1. Don’t be restricted by the clinical presentation. Expect the unexpected.
2. A limited biopsy can still be worth a million 💰
Bx shows: FSGS ( no ANCA crescents)
Now see arrows.
Now see Congo red.
Interstitial amyloid (not AL).
A patient who 7 years prior had renal bx proven ANCA vasculitis (MPO) ( was treated with Rituximab, now presents with ⬆️ proteinuria and ⬆️ creat. MPO ANCA elevated. Limited sample. Thoughts?View quoted post on X