Rob Manguso

@MangusoLab

Official twitter of the Manguso Lab @MGHCancerCenter @BroadInstitute @harvardmed, studying cancer immunology using functional genomics and systems immunology

Cambridge, MA mangusolab.org Joined June 2019

1.1K Following 1.4K Followers 220 Posts

Latest posts 5

Rob Manguso @MangusoLab Jun 10

Excited to share out latest work, out this week in @NatureGenet . In this study, we using CRISPR screens to explore how sensing inflammatory cytokines exposes new tumor-intrinsic dependencies.
@broadinstitute @MGBResearchNews

nature.com/articles/s4158…

www.nature.com Inflammatory cytokines induce new cancer dependencies Nature Genetics - Cheruiyot et al. conduct genome-scale in vitro CRISPR loss-of-function screens to map genetic vulnerabilities induced by inflammatory cytokines and identify the...

Rob Manguso @MangusoLab Sep 30, 2025

Our latest work on IO target discovery is out this week. Amazing collaboration with @DrUppaluri and led by Cong Fu. We performed in vivo CRISPR screens in #HNSCC to identify targets to enhance ICB response.
@MGHCancerCenter @broadinstitute @DanaFarber

nature.com/articles/s4146…

www.nature.com In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target Nature Communications - UCHL5 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains. Here, the authors discover through in-vivo CRISPR-Cas9 screens that Uchl5 is involved in...

Rob Manguso @MangusoLab Sep 26, 2025

Super excited to share our latest work with @MarcelaMaus , out this week in @Nature. We show that in vivo CRISPR screens can identify genes that enhance the efficacy of CAR T cell therapy. Brief explainer below! @MGBResearchNews @broadinstitute

rdcu.be/eHZG4

Rob Manguso @MangusoLab Aug 21, 2024

Really exciting that @MJWu_TW is opening his own lab close by at @UMassChan ! Amazing science and a great training opportunity for students and postdocs!

Meng-Ju Wu @MJWu_TW Aug 20, 2024

Join us! My lab @UMassChan is seeking postdocs and research associates who are passionate about how changes in metabolism and epigenetics contribute to cancer development and immune system evasion. DM me for a chat and apply at ummsjobs.com/job/10593/ (postdoc position)
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Rob Manguso @MangusoLab Jul 17, 2024

Our latest paper with the Bardeesy lab @MGHCancerCenter out recently in Science. We describe a novel immune MOA for inhibitors of mutant IDH1 involving the upregulation of transposable elements that are sensed by the cGAS-STING pathway.

science.org/doi/10.1126/sc…

Explainer🧵

www.science.org Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes...