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Mark Pepin MD, PhD, FESC

@MarkEPepin

Cardiology @StanCVFellows | Dad x 4 | CVD Epigenetics & Metabolism | @BrighamMedRes ‘24 | @AvHStiftung '22 | @UABMSTP '20 | @ucdavis BME '13 | Clemson '11
Stanford, CA profiles.stanford.edu/mark-pepin?tab… Joined September 2011
606 Following 894 Followers 934 Posts

Latest posts 5

Mark Pepin MD, PhD, FESC @MarkEPepin
Excited to share our new review with Johannes Backs on how metabo epigenetic circuits encode gene programs that drive heart failure development and progression.
link.springer.com/article/10.103…
link.springer.com Metabo-epigenetic circuits of heart failure: chromatin-modifying enzymes as determinants of... EMBO Molecular Medicine - Metabolic adaptations are a functional requirement for the heart to accommodate its broad range of physiologic operating conditions. It is increasingly recognized that...
Mark Pepin MD, PhD, FESC @MarkEPepin
What began as a fun consulting opportunity evolved into a mission to set a standard for rigor and accountability for ambient AI scribes. frontiersin.org/journals/artif…
www.frontiersin.org Frontiers | Assessing the quality of AI-generated clinical notes: validated evaluation of a large... BackgroundGenerative artificial intelligence (AI) tools are increasingly being used as “ambient scribes” to generate drafts for clinical notes from patient e...
Mark Pepin MD, PhD, FESC @MarkEPepin
PREPRINT: We used a clinical FFPE section of human aortic tissue to implicate a rare variant in the ACTA2 gene at single-cell resolution, inspired by a young - otherwise healthy - individual who initially presented to us with a dissected aortic aneurysm. medrxiv.org/content/10.110…
www.medrxiv.org Dysregulated smooth muscle cell proliferation and gene expression underlie ACTA2 variant-associated... Pathogenic variants affecting alpha-2 smooth muscle actin (ACTA2) account for approximately 20% of non-syndromic familial thoracic aortic aneurysms (TAA) and confer a high risk of dissection;...