MedChemExpress

🔬Help Us Better Support Scientists Worldwide!💜
🔗Take our Global Survey: medchemexpress.com/global-market-…

🌎Join the MedChemExpress Research Community by sharing your information. Stay connected with us to access the latest research resources and discover how MCE’s products and services can support your scientific journey.

Thank you for being part of the scientific community driving innovation forward. 🧪

#LifeScience #ScientificResearch #Biotechnology #DrugDiscovery #ResearchCommunity

🏆 MedChemExpress Wins the 2026 Bioz Stars Award in the #Inhibitors Category!

We’re honored to receive this recognition, highlighting our continued commitment to delivering high-quality research tools and supporting scientific discovery.

Powered by Bioz’s patented AI technology and analysis of 35 million scientific publications, the Bioz Stars Awards recognize the impact of research products in scientific literature. In 2026, MCE inhibitors have been cited in 12,000+ scientific publications!

At MedChemExpress, we continue to strengthen our inhibitor portfolio and research support capabilities:
🧪150,000+ Specific Inhibitors & Agonists
Covering 1,500+ targets and 400+ disease areas, including key research areas such as #JAK, #STING, PD-1, #KRAS, and #ferroptosis.
📊Comprehensive Research Support
Featuring 150,000+ solubility data points and 1 million+ gene and pathway data points to support informed research decisions.
🔬Comprehensive Quality Control
Backed by four biological validation platforms covering #molecular, #protein, #cellular, and in vivo assays. Each batch comes with a complete Certificate of Analysis (COA), supporting consistent product quality and reproducible research.
🌍Global R&D & Distribution Network
Backed by extensive custom synthesis capabilities and professional technical support.

This recognition is a testament to the trust and support of our customers and the global research community. We remain committed to bringing researchers more high-quality products and innovative solutions, empowering scientific discovery around the world. ow.ly/A8b05104nIw

#BiozStarsAward #Inhibitors #Agonists #LifeScience #ResearchTools #ScientificResearch #AI #MedChemExpress

🧬Research Spotlight | Can fatty acid metabolism determine whether cells undergo senescence or ferroptosis?

A new study in Cell reveals how polyunsaturated fatty acid (PUFA) metabolism influences the cellular fate decision between senescence and ferroptosis.
🔸Senescent cells increase the uptake and membrane accumulation of multiple PUFAs but show reduced levels of dihomo-γ-linolenic acid (DGLA), an omega-6 fatty acid.
🔸Restoring DGLA levels triggers ferroptosis in senescent cells, suggesting that altered fatty acid metabolism helps these cells evade ferroptotic death.
🔸Oral DGLA supplementation reduced senescence markers and improved age-related functional outcomes in aged mice.
🔸In human adipose tissue, lower DGLA desaturation rates were associated with reduced markers of cellular senescence.

Read more: cell.com/cell/fulltext/…

#Ferroptosis #Senescence #CellularSenescence #LipidMetabolism

🧬#FDA Approval Update | A new treatment option for recurrent or metastatic head and neck cancer

The FDA has granted accelerated approval to Rybrevant Faspro (amivantamab and hyaluronidase-lpuj) for adults with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) whose disease has progressed during or after platinum-based chemotherapy and immunotherapy.

📊In a clinical trial involving 102 patients, the treatment demonstrated an overall response rate (ORR) of 42%, with 56% of responders maintaining their response for at least six months.

💡This marks the first FDA approval in 10 years of a new drug for patients with recurrent or metastatic HNSCC previously treated with platinum-based chemotherapy, addressing a significant unmet medical need.

MedChemExpress offers biologically-validated Amivantamab for research use: medchemexpress.com/amivantamab.ht…

#FDAApproval #HNSCC #HeadAndNeckCancer #Oncology #CancerResearch

🧬Research Spotlight | Can a hidden RNA element reveal a new vulnerability in MYC-driven cancers?
A new study in Cell uses CRISPR tiling mutagenesis to map the 10-kb MYC locus at base-pair resolution, revealing that 67% of functionally essential base pairs lie within noncoding sequences.

💡The researchers identified an ultraconserved RNA element in the MYC 3’ UTR that regulates MYC mRNA localization and promotes nuclear localization of MYC protein through its interaction with hnRNP L.

🧪Notably, steric-blocking antisense oligonucleotides (ASOs) targeting this RNA element selectively suppressed the growth of MYC-dependent cancer cells and inhibited the growth of patient-derived tumor organoids.

🔗Read more: cell.com/cell/abstract/…

#RNA #CRISPR #AntisenseOligonucleotides #CancerResearch