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Michael Raddatz

@MichaelR21

Cardiology fellow in the Lusis Lab @UCLA. Partner to @DemetraHufnagel.

Bluesky: bsky.app/profile/michae…
Los Angeles, CA maraddatz.com Joined March 2009
1.4K Following 1.1K Followers 2.1K Posts

Latest posts 5

Michael Raddatz @MichaelR21
Thanks for the shoutout, @DOM_UCLA! @AlexBickMDPhD @yash_pershad @DrFlashHeart
Department of Medicine at UCLA Health @DOM_UCLA Jan 29
Exciting research news!

DoM fellow, Dr. Michael Raddatz, and his team published groundbreaking research in @JClinicalInvest uncovering how CHIP mutations increase the risk of aortic valve disease. Their work could lead to new preventive treatments: uclahs.fyi/49JfFhi
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Michael Raddatz @MichaelR21
Happy to see @jclinicalinvest highlighting our work on CHIP and aortic valve stenosis. Short thread below ⬇️

x.com/MichaelR21/sta…
Journal of Clinical Investigation Verified account @jclinicalinvest Jan 8
#ClonalHematopoiesis of indeterminate potential (CHIP) is common in older individuals, but its connection with aortic valve stenosis was unclear.

Here, @AlexBickMDPhD @StefanieDimmel1 @AndreasZeiher @cpi_exstra reveal an association between TET2 mutations and aortic valve stenosis (n=886,378), showing #CHIP activates procalcific pathways in macrophages and promotes aortic valve stenosis: jci.org/articles/view/…

The figure shows increased aortic valve calcification (OSM, green) and inflammation (S100A9, red) in a CHIP TET2-mutant mouse model; nuclei (DAPI, blue).
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Michael Raddatz @MichaelR21
Thanks for sharing, @EricTopol! Glad to see this story out in @jclinicalinvest. Short thread below:
Eric Topol Verified account @EricTopol Nov 18, 2025
We still don't measure CHIP in the clinic (blood stem cell clones) which occur frequently with age and are a risk factor for cancer and heart disease. Here's how CHIP can lead to a calcified aortic valve. @jclinicalinvest
jci.org/articles/view/…
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Michael Raddatz @MichaelR21
It's an exciting time to watch CHIP grow in the CV space (ideally not in the bone marrow). Ideal to both build specialized CHIP teams now *and* democratize knowledge moving forward given the burden of disease. Doing all the above at @DOM_UCLA. @datsunian @A_SteinMerlob
Brett Heimlich @brettheimlich Oct 14, 2025
Seeing this in real time at VUMC where 1 in 5 cath lab patients have CHIP. We're building care pathways but standardization across centers would help. Curious what others are doing for longitudinal follow-up. @MichaelR21 @pnatarajanmd @AlexBickMDPhD
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