Micklefield Lab

@Micklefield_Lab

Solvitur ambulando - Biosynthesis; pathway engineering; enzyme discovery-structure-mechanism; biocatalysis & nucleic acids.

Imperial College London …lefieldlab.chemistry.manchester.ac.uk Joined June 2018

2.2K Following 5.1K Followers 235 Posts

Latest posts 5

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Micklefield Lab @Micklefield_Lab Jul 29

Our latest article in Nature (@Nature) reports the discovery of pathways to new polyene antifungals that outperform current clinical drugs and act via a different mechanism. Combating #AMR @imperialcollege
nature.com/articles/s4158…

www.nature.com Enzymatic glycosylation and amidation reshapes polyene bioactivity Nature - Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and...

Micklefield Lab @Micklefield_Lab 4d

Delighted to see this excellent News & Views article in Nature Chemical Biology highlighting our lab's work on a new enzymatic approach for producing safer, more effective polyene antifungal agents.
doi.org/10.1038/s41589…
#Biocatalysis #NaturalProducts #ChemBiol #Antifungals

www.nature.com Biosynthetic tailoring of polyene antifungals Nature Chemical Biology - Polyenes remain indispensable antifungal agents despite dose-limiting toxicity and formidable synthetic complexity. Mirza et al. show that tailoring biosynthetic enzymes...

Micklefield Lab @Micklefield_Lab Aug 10

Newly discovered ligase enzymes are expanding the biocatalytic toolbox for peptide synthesis. In our latest review, we discuss their potential to deliver more sustainable and efficient manufacturing of peptide therapeutics.

doi.org/10.1016/j.cbpa…

Micklefield Lab @Micklefield_Lab Jul 31

Excellent commentary and insight on our latest paper in Nature – Enzymatic glycosylation and amidation reshapes polyene bioactivity – from Brianna Barbu at C&EN:
cen.acs.org/biological-che…

cen.acs.org Enzymes open a new path to improve antifungal drugs A biocatalytic platform could offer a scalable strategy for tailoring natural products

Micklefield Lab @Micklefield_Lab Jul 7

Our group had a fantastic couple of days away in the South Downs National Park, enjoying walks, taking in the stunning scenery, and making the most of the sunshine and refreshing sea breeze. ☀️🌿🌊