Mo Khalil

@MoKhalilLab

Prof. @ Harvard University, Broad Institute, & Wyss Institute. Understanding the natural world by building a synthetic one. Website: khalillab.github.io

Boston, MA khalillab.github.io Joined May 2017

1.9K Following 10K Followers 2.8K Posts

Latest posts 5

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Mo Khalil @MoKhalilLab Jul 27, 2022

Attn eVOLVER users & enthusiasts. 2 BIG developments!

1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolver/

2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki…

khalil-lab.gitbook.io eVOLVER Documentation Wiki | eVOLVER Welcome to the eVOLVER documentation wiki! This aims to be a resource for all things eVOLVER, covering how to set up, use, modify, and troubleshoot hardware, software, and wetware on the platform.

Mo Khalil @MoKhalilLab Oct 6

Exciting news! Our team was selected to receive the @NIH Director's Pioneer Award!
Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?

NIH Verified account @NIH Oct 6

The NIH Director’s High-Risk, High-Reward Research Awards empower innovative scientists redefining the limits of biomedical and behavioral research.

Meet the 2026 recipients of the NIH Director’s Pioneer, New Innovator, and Transformative Research Awards and discover the groundbreaking research they’re pursuing: go.nih.gov/BxJzhAG

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Mo Khalil @MoKhalilLab Sep 16

Looks amazing 🤩

Will Ratcliff Verified account @wc_ratcliff Sep 15

1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply early!

June 27–July 2 • Andover, NH

grc.org/microbial-popu…

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Mo Khalil @MoKhalilLab Aug 3

🚨Excited to see this work out today in @NatureBiotech! Congrats to Julia and the collaborative team, demonstrating evolution of botulinum neurotoxin (BoNT) proteases into programmable triggers of inflammatory cancer cell death. See @davidrliu's thread below 👇

David R. Liu Verified account @davidrliu Aug 3

Today in @NatureBiotech we report the use of phage-assisted evolution (PACE) to reprogram botulinum neurotoxin (BoNT) proteases to trigger cancer cell death. We evolved proteases to cleave procaspase-1 or gasdermin D, inducing cell death and slowing tumor growth in a highly drug-resistant mouse model.
drive.google.com/file/d/1KQfc19…
1/13

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Mo Khalil @MoKhalilLab Jul 31

Initial set of our T-DNA vectors now available on @Addgene:

pT1 (no selection marker): lnkd.in/dcnTN8Rj
pT1-B (BASTA selection marker): lnkd.in/dgTZmuCx
pT1-K (kan selection marker): lnkd.in/dqgv4QRc
pT1-H (hygro selection marker): lnkd.in/dhrs5Tsg

lnkd.in LinkedIn This link will take you to a page that’s not on LinkedIn

Mo Khalil @MoKhalilLab Jul 17

🌱🚨 Very proud and excited to share our PREPRINT, unveiling an advance for plant science, biotech, & synthetic biology in the first (of many) Khalil <> Gehring collaborations!

biorxiv.org/content/10.648…
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