MoldoveanuLab

Apoptosis inhibition: MCL-1 vs BAK
Our new study published in Molecular Cell featuring classic BCL-2 family proteins inhibition of apoptosis by oncogene MCL-1 who blocks mitochondrial outer membrane permeabilization by the pore-forming protein BAK:
authors.elsevier.com/a/1ktSg3vVUPVZ…

Are all folded BCL-2 family proteins pore-forming?
It surely seems that if one tries hard enough they could be made pore-formers, but now clearly 4 of them stand out: BAK, BAX, BOK & tBID. I reflect on this problem in #BioEssays
onlinelibrary.wiley.com/doi/full/10.10…

We dedicate @iScience_CP paper on #apoptosis initiation with BAK activators to Dr. Geetika Singh @GeetikaGitika2, who recently lost her life to cancer. We are humbled by this tragedy and grateful for life and important contributions at many levels.
doi:10.1016/j.isci.2022.105064

Loved to see your discoveries develop Sebastian and glad we were able to discuss them regularly. A real treat!

Our review is out @PPPublishing. We tested #AlphaFold which worked remarkably well for determining ligand-bound complexes with caveats...
Protein–protein and protein–lipid interactions of pore-forming #BCL2 family proteins in #apoptosis initiation portlandpress.com/biochemsoctran…