Twitxy
Saved
@NiTriona's profile picture
View on X

Triona Ní Chonghaile

@NiTriona

Cancer Biologist that likes killing cells - cancer cells. A Senior Lecturer at the Royal College of Surgeons in Ireland. Comments are my own.
Ireland ttc-lab.com Joined March 2013
803 Following 1.4K Followers 1.5K Posts

Latest posts 5

Pinned post

Triona Ní Chonghaile @NiTriona
Huge congratulations to Andy on the publication of his PhD work!
This was a massive team effort, thanks to the lab for helping out & collaborators: @DrCDowling @IngmarSchoen @emmamarykerr @marie_mcilroy
Read it here: rdcu.be/eyagL 🙏 @Researchirel For Funding.
RCSI @RCSI_Irl Jul 29, 2025
A new RCSI study in @NatureComms reveals how blocking HDAC6 alters metabolism in cancer cells.

It also shows a new role for HDAC6 in regulating cells' energy pathways, making it a potential target for tumour metabolism.

Read the paper ➡️ doi.org/10.1038/s41467…

#RCSIdiscover
Microscopy image of mitochondria, stained to highlight their elongated, branched structures in vivid orange and pink tones, with bright cyan areas indicating stained nuclei or other subcellular components. The background is black for contrast. Overlay includes the RCSI University of Medicine and Health Sciences crest and the RCSI Discover branding.
View quoted post on X
2 replies 3 reposts 34 likes 4.2K views View on X
Triona Ní Chonghaile @NiTriona
Congratulations to @DanielAlencar_R on the publication of his paper nature.com/articles/s4146…. To go from a broad phenotypic screen to identifying D567 in human CD2 domain for interaction of BAS-2 with HDAC6 has taken years and numerous collaborations.
www.nature.com Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor Nature Communications - HDAC6 controls key cellular processes and is an important drug target. Here, the authors reveal how the selective inhibitor BAS-2 recognises human HDAC6, explain its species...