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NidetzkyLab

@NidetzkyLab

Our lab @tugraz is focused on fundamental and applied Glycosciences and Glycobiotechnologies
Graz, Austria tugraz.at/institutes/bio… Joined April 2020
100 Following 221 Followers 69 Posts

Latest posts 5

NidetzkyLab @NidetzkyLab
Why does cellulose hydrolysis slow long before full conversion?
Time-lapse in situ AFM nanomechanical mapping reveals two mechanisms:
substrate nanomechanics + enzyme adsorption dynamics control conversion efficiency. | ACS Catalysis pubs.acs.org/doi/10.1021/ac…
pubs.acs.org Slowdown of Enzymatic Cellulose Conversion Emerges from Cellulase Mode of Action Abstract. The problem of early slowing of the conversion rate in cellulose hydrolysis, and the resulting large amounts of cellulase enzymes required to ach
NidetzkyLab @NidetzkyLab
Human GDP-l-fucose synthase (GFS) catalyzes a three-step reaction: epimerization at C-3″/C-5″ and NADPH-dependent reduction at C-4″.
Kinetic and structural studies reveal: product release (GDP-l-fucose) is the rate-limiting step, not catalysis. pubs.acs.org/doi/10.1021/ac…
pubs.acs.org Kinetic Dissection of the Reaction of Human GDP-l-Fucose Synthase Abstract. GDP-l-fucose is a universal sugar donor for the cellular biosynthesis of l-fucose-containing glycans. Its supply comes primarily from the reactio
NidetzkyLab @NidetzkyLab
New paper out now in Angewandte Chemie! We present a chemoenzymatic route for synthesizing N¹-methylpseudouridine triphosphate — a key mRNA vaccine component. A step forward in efficient nucleotide synthesis. onlinelibrary.wiley.com/doi/10.1002/an… #RNA #mRNA #SynBio @tugraz
onlinelibrary.wiley.com Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine... Pseudouridine-5′-triphosphate (ΨTP) and its N1-methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom-economic, high-yielding biocatalytic route for ΨTP...
NidetzkyLab @NidetzkyLab
Excited to share our latest research: Phosphorylation-condensation cascade for biocatalytic synthesis of C-nucleosides: Chem Catalysis cell.com/chem-catalysis…
www.cell.com Phosphorylation-condensation cascade for biocatalytic synthesis of C-nucleosides Enzymatic cascade reactions are powerful tools for the synthetic assembly of complex molecules in the chemical space of nucleosides, but the applicability of such systems within process chemistry...
NidetzkyLab @NidetzkyLab
Electrochemically Induced Nanoscale Stirring Boosts Functional Immobilization of Flavocytochrome P450 BM3 on Nanoporous Gold Electrodes - Hengge - Small Methods - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/sm…
onlinelibrary.wiley.com Electrochemically Induced Nanoscale Stirring Boosts Functional Immobilization of Flavocytochrome... A flexible-modular approach for enzyme immobilization on nanoporous gold (npAu). A cationic protein module for directed binding is fused to the enzyme. The surface is modified with self-assembled...