The Nogales Lab

How does human NuA4/TIP60 recognize and modify nucleosomes? Our work reveals cooperative recognition involving the acidic patch and linker DNA and uncovers an interaction between the Tudor domain and catalytic core that regulates HAT activity.
Preprint: biorxiv.org/content/10.648…

Thrilled to share our latest work, led by @aryandtaheri and @jpeukes! Using #cryoEM and #cryoET, we reveal how KIF21B’s distal tail engages multiple tubulin dimers along a protofilament, enabling persistent microtubule attachment and crosslinking.

biorxiv.org/content/10.648…

Thrilled to share our collab with @GraceHibshman and the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.

🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by @Juanmabertoldi1 and Julie Dang spanning atoms to organisms. 1/n

Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science news.vumc.org/2026/06/30/mol…

I am truly honored to receive this prize and incredibly grateful to have worked with so many talented lab members over the years.🙏👩‍🎓🧑‍💼