Osteoarthritis and Cartilage Journals

🆕 New this month!

#Fasinumab and other #NGF inhibitors have consistently shown effectiveness in the treatment of OA pain in RCTs but what are the biological changes associated with its use?

Read more in this article by Poulabi Banerjee et al. - oarsijournal.com/article/S1063-…

This month in #OAC Zhang et al. determined that synovial fluid protects cartilage from fatigue failure during compressive loading.
🔗sciencedirect.com/science/articl…

🎃 #editorschoice

Low pain does not mean low risk - #silentprogressors had about 4️⃣ times the TKR rate of #resilient knees despite few symptoms

Read more about phenotyping of knee osteoarthritis in this month's editor's choice by Sourougeon et al. - oarsijournal.com/article/S1063-…

New in #OAC Zhang et al. demonstrated that Sestrin2 (SESN2) promotes chondrocyte mitochondrial dysfunction by regulating MFN2 dephosphorylation to induce mitochondrial hyperfusion, thereby providing a new potential target for intervention in OA.

sciencedirect.com/science/articl…

Zhu et al. investigated the role of Growth Differentiation Factor 10 (GDF10) in Osteonecrosis of the femoral head–associated cartilage degeneration (ONFH-ACD). GDF10 limits fibrosis and supports cartilage matrix synthesis via SMAD1/5/8 and SMAD2/3.
sciencedirect.com/science/articl…