@OUNeuroscience
📢 New Open🔓 Access Article Alert
“Irradiation-induced brain senescence accelerates cardiac aging via systemic mechanisms: insights from transcriptomic profiling” by Rafal Gulej (@RafalGulej) & Zoltán Ungvári (@zoltan_ungvari) et al.
👉 rdcu.be/eRKoK
Key Insights:
📌Brain irradiation in mice induces cellular senescence, triggering systemic molecular changes.
📌Transcriptomic analysis shows that this brain senescence activates pathways that lead to cardiac aging, including inflammation and extracellular matrix remodeling.
📌The study suggests that brain aging can drive heart aging, supporting the concept that aging in one organ system can propagate to others through circulating factors.
Why It Matters:
This work reveals a crucial brain-heart aging axis, highlighting that targeting brain senescence may have protective effects on cardiac aging — a potentially novel interventional strategy in geroscience.
#Aging #Senescence #CardiovascularAging #Geroscience #BrainHeartAxisView quoted post on X
