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ObarLab

@ObarLab

Professor @GeiselMed @Dartmouth @DMS_MicroImmuno; Laboratory of Antifungal Immunity // Director @MCBDartmouth // JV Soccer Coach @hcaneswirl
Lebanon, NH geiselmed.dartmouth.edu/obar/ Joined March 2020
695 Following 905 Followers 1.3K Posts

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ObarLab @ObarLab
Our work with @andolive85’s lab is now live @J_Immunol in which we demonstrate alveolar macrophage are potent inducers of the type I interferon response
The Journal of Immunology @J_Immunol Jul 8
A #CuttingEdge article suggests TGFβ modulates the metabolic networks and immune signaling cascades of alveolar macrophages to control inflammatory pathways and that the role of type I IFNs is a key initial response to invading pathogens in the lungs. ow.ly/nmIW50ZhTkV.
Mitochondrial ROS contributes to TGFβ-dependent IFN responses. (A) WT TGFβ (−) FLAMs and WT or Mavs KO TGFβ (+) FLAMs were stained for the peroxisomal markers PMP70 and catalase in addition to cellular DNA with DAPI. Shown are representative images from at least 3 independent experiments. The far-left column images were taken with a 100× oil objective; inset images were cropped to a single cell and have a scale bar that is 10 μm in size. (B) MFI of each peroxisomal marker in (A) was quantified. Each individual data point represents a single cell from a representative experiment. (C) WT TGFβ (−) FLAMs and WT or Mavs KO TGFβ (+) FLAMs were stained for the mitochondrial markers Tomm20 and ATP synthase in addition to cellular DNA with DAPI. Shown are representative images from at least 3 independent experiments. The far-left column images were taken with a 100× oil objective; inset images were cropped to a single cell and have a scale bar that is 10 μm in size.
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