James Olzmann

@OlzmannLab

Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology

Berkeley, California. USA. olzmannlab.com Joined August 2018

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Latest posts 5

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James Olzmann @OlzmannLab Feb 25

1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
nature.com/articles/s4158…

www.nature.com CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly Nature - CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane...

James Olzmann @OlzmannLab Oct 16

Congrats to Maia Kinnebrew and team! 🎉 Genetic screens and mechanistic follow-up reveal how fatty acid metabolism tunes membrane fluidity and accessible cholesterol pools. Happy to have contributed in a small way to this study.
nature.com/articles/s4146…

www.nature.com Fatty acid metabolism controls plasma membrane cholesterol accessibility via ATGL-dependent... Nature Communications - Accessible cholesterol levels in the plasma membrane are governed by complex regulatory processes. Here Wijesinghe et al. discover that fatty acid starvation activates ATGL...

James Olzmann @OlzmannLab Oct 16

Wonderful trip to Kyushu! Thanks to Ryo Seino and the Dojindo team in Kumamoto, and Ken-ichi Yamada and his lab at Kyushu University in Fukuoka, for hosting. Enjoyed hearing about everyone’s projects, the great discussions, warm hospitality, and fantastic food!

James Olzmann @OlzmannLab Sep 30

1/ Happy to see this collaborative work w/ Fangzhu Zhao, @realJimWells & colleagues now published in @PNASNews!

LRP8-targeted KineTACs degrade LRP8, reduce GPX4 & other selenoproteins, and sensitize cancer cells to ferroptosis.

pnas.org/doi/10.1073/pn…

www.pnas.org Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells | PNAS Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limit...

James Olzmann @OlzmannLab Sep 25

Excited to see this online and to have contributed in a small way! Huge congratulations to @Sulfur_Vladi, Takaaki Akaike & team. Elemental sulfur (S8) accumulates in lipid droplets, & protects against lipid peroxidation and ferroptosis! 🔥
science.org/doi/10.1126/sc…

www.science.org Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its...