The Patient-Centered Outcomes Research Institute

There's still time to submit a nomination for PCORI’s Methodology Committee!

Committee members contribute their perspectives and expertise to help:
◾ Facilitate the use of rigorous and innovative methods in patient-centered CER.
◾ Identify priorities for addressing gaps in research methods and their applications.
◾ Provide recommendations to PCORI’s Board of Governors on methodological standards for CER.

Apply or submit a nomination before Nov. 8 at 11:59 p.m. (ET). pcori.me/4gc9o0P

Register for Upcoming Applicant Town Halls!

Several PCORI Funding Announcements will open for Letter of Intent submissions Nov. 17.

If your research aligns with an upcoming PFA, join an Applicant Town Hall to learn about the PFA, hear directly from PCORI staff and get answers to your questions as you prepare your LOI.

Learn more: pcori.me/4i0Tx6d

A recent edition of PCORI's Emerging Health Care Innovation Brief covers FDA approval of an expandable pulmonary heart valve for children with congenital pulmonary valve disease, and a second long-acting insulin, given once a week, for adults with Type 2 diabetes.

Other topics include:
◻️ Laruparetigene zovaparvovec, an experimental gene therapy designed to treat a rare, inherited eye disorder that affects the retina.
◻️ Zilganersen (Zanvastro), a targeted genetic treatment to prevent abnormal production of a specific protein for children and adults with Alexander disease.

Read more: pcori.me/4yZYy4k

One Week Left: Share Your Input on Future Research Needs 🚨

Through a RFI, PCORI is interested in research questions that compare healthcare options, examine whether treatments may work differently across groups or communities, reflect current healthcare challenges and are relevant to care delivered in a variety of settings.

Submit your input by Nov.10: pcori.me/4zVQvak

A PCORI-funded RCT compared 2 community-based cavity treatment programs:
1️⃣ Standard treatment consisting of treatment with hand instruments followed by application of a topical fluoride varnish
2️⃣ New community-based program using topical silver diamine fluoride (SDF) applied by dental hygienists, which does not require hand instruments or drilling but can permanently darken areas of tooth decay

After one year, participants in both programs had similar outcomes in controlling tooth decay, reducing tooth pain, preventing new cavities and improving quality of life related to oral health. Treatment with SDF twice yearly was found to be more effective than treatment once yearly. pcori.me/4eba1Xd